Wednesday, September 22, 2010

Levetiracetam (keppra) and Vitamin B6 - something to think of when writing Keppra!

Levetiracetam (keppra) has been reported to cause many behavioral and psychiatric disturbances including anxiety, irritability, depression etc. Recent literature (thoug mostly from pediatric population) suggests that the addition of pyridoxine (vitamin B6) may curtail some of the these symptoms.


Pyridoxine supplementation for the treatment of levetiracetam-induced behavior side effects in children: preliminary results - Epilepsy Behav. 2008 Oct;13(3):557-9. Epub 2008 Aug 3.

Behavioral effects of levetiracetam mitigated by pyridoxine. - J Child Adolesc Psychopharmacol. 2009 Apr;19(2):209-11

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